From Inflammation To Immunity: How Low-Dose Naltrexone Works

Send us Fan Mail What if one small dose could shift big systems—calming neuroinflammation, easing chronic pain, and nudging an overactive immune response back toward balance? We take a clear-eyed look at low-dose naltrexone (LDN) and map the two mechanisms that make its wide-ranging potential believable rather than hype: TLR4 modulation that quiets microglia in the brain, and a brief opioid receptor blockade that triggers rebounds in endorphins and opioid growth factor (OGF). First, we unpac...