TWiV 751: Sputnik spat and furin in ferrets

TWiV examines the claim by Brazil's ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV vaccine town halls Brazil rejects Gamaleya vaccine (Sci Transl Med) Russian vaccine behavior (Sci Transl Med) Is Gamaleya vaccine safe ? (Science) Furin cleavage site in replication and transmission (Nat Micro) Furin site loss attenuates pathogenesis (Nature) Timestamps by Jolene . Thanks! Weekly Picks Rich – The diversity and function of sourdough starter microbiomes ; Dunn Lab Wild Sourdough Project Kathy – ISS, Crew Dragon, and the sun Doubly warped world of binary black holes Vincent – Mr. Labman Listener Picks Joy – Abandoned America: Matthew Christopher's Autopsy of the American Dream Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]