What Do We Know About SSRI Antidepressant Withdrawal?

Roughly 1 in 10 Americans take antidepressants. The most common type is SSRIs, or selective serotonin re-uptake inhibitors, like Prozac, Lexapro, and Zoloft. But what happens when you stop taking them? Studies don’t point to a single conclusion, and there’s ongoing debate among physicians and patients about the severity and significance of SSRI withdrawal symptoms. The discourse reached a fever pitch when Health Secretary Robert F. Kennedy Jr. compared SSRI withdrawal to heroin withdrawal in January.

Host Flora Lichtman digs into the data on SSRI withdrawal with psychiatrists Awais Aftab and Mark Horowitz.

Guests: Dr. Awais Aftab is a clinical associate professor of psychiatry at Case Western Reserve University.
Dr. Mark Horowitz is a clinical research fellow in the UK’s National Health Service and scientific co-founder of Outro Health.

Transcripts for each episode are available within 1-3 days at sciencefriday.com.

Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.