TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condi t and Kathy Spindler Guests: Moshe Arditi and Ivet Behar Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MIS-C in US children (NEJM) Superantigen in spike and T cell skewing in MIS-C (PNAS) MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol) Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure) Autoimmune signature of MIS-C in children (J Clin Invest) HLA1 associated T cell expansion in MIS-C (J Clin Invest) Passing of Bill Wold ( one , two ) Letters read on TWiV 815 Timestamps by Jolene . Thanks! Weekly Picks Dickson – Mel Brooks Kathy – Dickson's art show at Fordham Rich – Saildrone captures footage from inside Hurricane Sam Vincent – A Shot to Save the World: The Inside Story of the Life-or-Death Race for a COVID-19 Vaccine by Gregory Zuckerman Listener Picks Kathryn – Project Drawdown and the book Charles – Arrowsmith by Sinclair Lewis Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]