TWiV 365: Blood, feuds, and a foodborne disease

Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus. Links for this episode Battle over genome editing (Wired) 10:05 First description of CRISPR in E. coli (J Bacteriol) 14:00 Cas genes identified (Mol Micro) 14:20 CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50 Genome engineering using CRISPR/Cas (Science) 18:50 Cpf1 endonuclease (Cell) 23:10 Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50 Summit on gene editing 21:25 Novel human virus in transfusion recipients (mBio) 27:00 Origins of hepatitis A virus in small mammals (PNAS) 55:05 Image credit Letters read on TWiV 365 7:00, 1:20:35 This episode is sponsored by ASM Microbe , ASM Biodefense , and the 32nd Clinical Virology Symposium . ( 1:10 , 1:18:30) Weekly Science Picks 1:36:30 Kathy - Tardigrade genome sequence ( video ) Alan - XKCD on Gates polio eradication site Vincent - Lifting the Impenetrable Veil by Charles Calisher Listener Picks Judi - Jennifer Doudna's Ted Talk Ramon - Map of the Sky Send your virology questions and comments to [email protected]