Can we really justify what we eat today by pointing to what our ancestors ate thousands of years ago? In this thought-provoking episode, I sit down with Alex Leaf, a scientific communicator and longtime researcher with Examine.com, to challenge some of the most persistent ideas in nutrition.We dive deep into the ancestral argument, the role of mTOR and protein in longevity, and the personal fat threshold hypothesis that could redefine how we view metabolic health and type 2 diabetes. From wrestling-induced bulimia to modern agriculture’s double-edged legacy, Alex brings a refreshingly perspective to some of the most polarizing conversations in nutrition.🔗 CONNECT WITH DAVE FELDMAN:Main Channel: YouTube.com/realDaveFeldmanX/Twitter: x.com/realDaveFeldman Instagram: instagram.com/realDaveFeldmanWebsite: thefeldmanprotocol.com⏱ Chapters1:07 – Who is Alex Leaf and how he started in nutrition3:59 – Wrestling, eating disorders & body image8:27 – Protein, mTOR & the longevity paradox11:15 – The importance of amino acid composition13:22 – Fasting, feeding cycles & “cell closing hours”15:46 – Do ancestral eating patterns actually make sense?18:00 – Food scarcity, evolution & modern adaptation20:10 – Agriculture: humanity’s double-edged sword22:45 – Are we engineering our own metabolic collapse?26:00 – Animal vs plant protein quality31:10 – Why “ancestral diet” arguments fall apart36:45 – Modern food, ultraprocessed diets & disease40:13 – The Standard American Diet as the control group44:04 – The personal fat threshold explained47:40 – How body fat triggers insulin resistance52:10 – Can weight loss reverse type 2 diabetes?58:30 – Does fasting insulin predict fat loss?1:03:00 – Linking triglycerides, HDL & metabolic health1:05:45 – ApoB, risk factors & what studies miss1:12:10 – The limits of adjustment in nutrition science1:17:30 – What makes lean mass hyper-responders unique
