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The Dr. Hyman Show

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NEW Season 1 Oct 21, 2026 · 1 hr 26 min

The New Science of Brain Aging: What 200,000 scans reveal | Paul Thompson, PhD

How well is your brain aging? Your birthday tells you one thing, but your brain may tell a different story. Today, I’m talking with neuroscientist Paul Thompson, PhD, whose work with the global ENIGMA Consortium is revealing how brain health connects to what’s happening throughout your body. We get into what brain scans can tell us and why those findings matter to you. We discuss: What your “brain age” means and how it can differ from your actual age Why your metabolic health deserves attention when you’re struggling with mood or memory How sleep and nutrition support your brain’s ability to function and recover What having an Alzheimer’s risk gene does, and doesn’t, tell you about your future How brain scans, blood tests, and AI could help identify the right treatment for you It’s so exciting to see researchers like Paul looking across thousands of brain scans and uncovering connections between the health of the body and the brain. For me, it opens up a bigger conversation about how we care for ourselves and how our everyday habits can help protect our memory and support our mood as we age. View Show Notes From This Episode Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hymanhttps://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journalhttps://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Healthhttps://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, Paleovalley, Timeline, Seed, BIOptimizers, and Fatty15. Explore red light products at boncharge.com/hyman and enjoy 15% off with code HYMAN. Shop nutrient-rich foods and supplements at paleovalley.com/hyman and save 15% off your first order. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at timeline.com/drhyman. Make your microbiome part of your daily routine with seed.com/hyman and save 25% with code 25HYMAN. Use bioptimizers.com/hyman and code HYMAN for 15% off, special bonuses, and a 365-day money-back guarantee. Head to fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. 0:00 Paleo Valley Superfood Bars 2:50 Enigma and Brain Mapping 10:30 Psychiatry Meets Brain Biology 18:35 The Brain-Body Connection 24:30 Mapping Mental Health Patterns 31:30 Brain Age and Biomarkers 36:59 Sleep, Nutrition, and Recovery 47:38 A Case of Brain Repair 52:50 Genes, Risk, and Protection 59:15 Brain Charts and Diagnostics 1:12:26 AI for Alzheimer’s Disease 1:20:06 Imaging and Prevention

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