Last Trading Day of Q3, Supply Chain Effect on Markets, D.C. on Wall Street's Radar, Merck's $11.5B Deal, Powell and Yellen Part Two, and Facebook on the Capitol Hill Hot Seat.

Carl Quintanilla, David Faber and Mike Santoli take a closer look at the markets as the three major indices aim to end the third quarter in positive territory after a rough September. Supply chain issues in focus: Bed Bath and Beyond shares plummeted on quarterly results and weaker guidance, hurt by a steep drop-off in traffic and supply challenges. New data show China manufacturing activity contracted in September for the first time in 18 months -- when the country was hit hard by the pandemic. The anchors discussed a New York Times story about how retailers are being impacted by shutdowns at their Vietnamese suppliers. Carl harkened back to his reporting from Vietnam in 2019 about that country's manufacturing boom. Carl, David and Mike also reacted to Fed Chair Jerome Powell describing supply chain problems as “frustrating.” Also in focus: Merck's $11.5-billion deal to acquire drug maker Acceleron Pharma, highlights from CNBC's "Delivering Alpha" conference including Chamath Palihapitiya on the markets, the Senate deal to avoid a government shutdown as the House moves toward a vote on the bipartisan infrastructure bill, what to expect from Fed Chair Powell and Treasury Secretary Yellen during their testimony before a House panel -- and the Facebook global head of safety’s appearance at a Senate subcommittee hearing on social media and Instagram’s impact on teens' mental health.