BILLS vs. 49ERS preview: Can Buffalo wrap up AFC East title + 3 major keys to defeat SF!

Matt Parrino and Ryan Talbot break down Sunday's big game between the Buffalo Bills and San Francisco 49ers. What are the big storylines, keys to the game, and players to watch? Then the guys make their picks! What is the "SHOUT!" Bills text insiders? Want to join? You can get analysis from Matt and Ryan right to your phone and send texts directly to them both! Text 716-528-6727 or Click here: https://joinsubtext.com/shoutbuffalobills Sign up for the NYUP Bills newsletter! Don't miss all the Bills coverage. Head over to www.Syracuse.com/newsletters to start getting your Bills stories and the podcast delivered right to your inbox. SHOUT!" Buffalo Bills football podcast is available on Apple, Spotify, Google, Stitcher, and wherever you listen to podcasts Follow @MattParrino (https://twitter.com/MattParrino) and @RyanTalbotBills (https://twitter.com/RyanTalbotBills) on Twitter Find our Bills coverage whenever you like to consume social media Instagram: https://www.instagram.com/buffalobillsnyup/ Facebook: https://www.facebook.com/buffalobillsnyup X: https://x.com/billsupdates Learn more about your ad choices. Visit megaphone.fm/adchoices