Episode Ep 306 October 30, 2026 58 min 2s

306: MCAS, Histamines And The Molecule That Is Changing It All - with Brandon Perez

What if the future of gut health and immune regulation involves something we're not paying nearly enough attention to: glyconutrients?

In this episode of ReversABLE, Josh Dech sits down with Brandon Perez to explore Acemannan, a naturally occurring, mannose-rich polysaccharide found in the inner gel of aloe vera, and its potential role in immune function, inflammation, and tissue repair.

Brandon shares his personal journey through eight years of mast cell activation syndrome (MCAS), histamine intolerance, chronic inflammation, sleep disturbances, brain fog, anxiety, and digestive dysfunction. After spending approximately $70,000 searching for answers, he discovered Acemannan and describes experiencing significant improvements in his symptoms over the following months.

But this conversation goes beyond one person's experience.

Josh and Brandon explore how Acemannan interacts with macrophages, the difference between immune stimulation and immune modulation, and why helping the immune system regulate its response may be more important than simply trying to boost it.

They also investigate the emerging science of glyconutrients, the glycocalyx, and the relationship between carbohydrate structures, cellular communication, and immune recognition.

Brandon also explains why Acemannan should be viewed as a potential component of a broader gut-healing strategy rather than a standalone solution.

If you're struggling with chronic gut issues, histamine intolerance, MCAS, or persistent inflammation, this episode offers a fascinating look at an emerging area of immune and nutritional research.

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