Radiolab

This week, in an episode we first aired in 2022, we flip the Disney story of life on its head thanks to a barrel of seawater, a 1970s era computer, and underwater geysers. It’s the chaos of life. Latif, Lulu, and our Senior Producer Matt Kielty were all sitting on their own little stories until they got thrown into the studio, and had their cherished beliefs about the shape of life put on a collision course. From an accidental study of sea creatures, to the ambitions of Stephen J Gould, to an undercooked theory that captured the world’s imagination, we undo the seeming order of the living world and try to make some music out of the wreckage. (Bonus: Learn how Francis Crick really thought life got started on this planet). EPISODE CREDITS: Reported by - Latif Nasser, Matt Kielty, Heather Radke, Lulu Miller and Candice WangProduced by - Matt Kielty and Simon Adlerwith help from - Arianne WackOriginal music and sound design contributed by - Matt Kilety, Simon Adler, Alan Goffinski, and Jeremy Bloom EPISODE CITATIONS: Articles - Chaos in a long-term experiment with a plankton community (https://zpr.io/j6sYXKfDzPCG), by Benincà, E., Huisman, J., Heerkloss, R. et al. Nature Chaos theory discloses triggers and drivers of plankton dynamics in stable environment (https://zpr.io/qHKENA3SJ8ML), by Telesh IV, Schubert H, Joehnk KD, Heerkloss R, Schumann R, Feike M, Schoor A, Skarlato SO. Sci Rep. Books - Full House (https://zpr.io/pMQZfyPcRzD4), by Stephen Jay Gould Extinction: Bad Genes or Bad Luck? (https://zpr.io/pPVNugUKWpi4), by David M. Raup Rereading the Fossil Record: The Growth of Paleobiology as an Evolutionary Discipline (https://zpr.io/YBjJxuXjydPN), by David Sepkoski The Vital Question: Energy, Evolution, and the Origins of Complex Life (https://zpr.io/LzfueEqUWNHb), by Nick LaneLife Itself: Its Origin and Nature (https://zpr.io/KPZf57eEVMBX), by Francis Crick Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Doctor and special correspondent Avir Mitra takes Executive Editor Soren Wheeler, plus a live studio audience, on a journey from the operating room to inside the body to the farm to the sewers and back again—searching for answers to an alarming threat to humanity’s existence as we know it: antibiotic resistance in bacteria. This live show, performed in New York City and also in Little Rock, Arkansas, is part of a series we’re doing with Avir that we are calling “Viscera.” Each event is a conversation that takes the audience on a journey into a quirk or question or mystery inside of us, and gives them a visceral experience of the viscera within us. The previous installment of the series was called “The Elixir of Life.” (https://radiolab.org/podcast/the-elixir-of-life)Special thanks to all of Little Rock Public Radio (especially Grace Zafasi and Jonathan Seaborn), Thomas Patterson, The Greene Space staff, CALS Ron Robinson Theater, Tom Philpott, Stephen Roach, Kate Shaw, Alex Wong, Maryn McKenna, and Kerri McClimen.If you are a patients or a doctor, and you are interested in phage therapy, please contact [email protected] EPISODE CREDITS: Reported by - Avir MitraProduced by - Jessica YungSound design contributed by - Jeremy Bloom and Jessica YungFact-checking by -Natalie Middleton EPISODE CITATIONS: Videos - Check out the video from the Viscera live show (and a bonus Q&A with Bruce Stewart-Brown and Steffanie Strathdee) on Radiolab’s YouTube (https://zpr.io/3BK9MqJYVKQA). A deep dive (https://zpr.io/WNQNfgiNvKeZ) on bacteriophages with Avir Mitra and Steffanie Strathdee, also on Radiolab’s Youtube.. Books - The Perfect Predator (https://theperfectpredator.com/) by Dr. Steffanie Strathdee’s telling of her battle against a killer superbug. Plucked (https://zpr.io/PudGMEuzgU9X) by Maryn Mckenna a detailed accounting of chicken farming’s practice of using antibiotics. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

A strange brew that's hard to resist, even for a modern day microbe.In the war on devilish microbes, our weapons are starting to fail us. The antibiotics we once wielded like miraculous flaming swords seem more like lukewarm butter knives. But in this episode, originally released in 2015, we follow an odd couple, of a sort, to a storied land of elves and dragons. There, they uncover a 1,000-year-old secret that makes us reconsider our most basic assumptions about human progress and wonder: what if the only way forward is backward? Special thanks to Steve Diggle, Professor Roberta Frank, Alexandra Reider and Justin Park (our Old English readers), Gene Murrow from Gotham Early Music Scene, Marcia Young for her performance on the medieval harp and Collin Monro of Tadcaster and the rest of the Barony of Iron Bog.Can’t get enough of that sweet, sweet antibiotic resistance content? Then you’ll be over the moon about next week’s release. It’s the podcast cut of our most recent installment of our live show series called Viscera. This one features executive editor Soren Wheeler and Avir Mitra, and it’s all about how our millenia's-long war against bacteria came to a tipping point in this modern age.Subscribe or follow our show on your favorite streaming platform and you’ll be the first to know when it drops. EPISODE CREDITS: Reported by - Latif NasserProduced by - Matt Kielty and Soren Wheeler EPISODE CITATIONS:Articles - Uncovering the multifaceted mechanism of action of a historical antimicrobial (https://zpr.io/mucw6Td6LBxT) by Harrison, F et al, 2026 bioRxv (PREPRINT). In this article Freya and her team describe the mechanisms under which Bald’s Remedy actually works. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

If a species is horrible enough, do we have the right to kill it forever? Seventy years ago, a nightmare parasite feasted on the live flesh of warm-blooded creatures in North America: the screwworm. That is, until a young scientist named Edward F. Knipling discovered a crucial screwworm weakness and hatched a sweeping project to wipe them out. Knipling’s seemingly zany plan to spray screwworms out of planes all over the continent— with US taxpayer money— succeeded, becoming one of humanity’s biggest environmental interventions ever. Today, screwworms have been gone so long that none of us in North America even remember them. But now, they’re coming back. And they’re forcing us to ask: in an era of climate change and rapid mass extinction— should we kill off a species on purpose? Special thanks to James P. Collins, Max Scott, Amy Murillo, Daniel Griffin, Phil Kaufman, Katie Barnhill, Arthur Caplan, Ron Sandler, Yasha Rohwer, Aaron Keefe, Gwendolyn Bogard, Maria Sabate, Meredith Asbury, and Joanne Padrón Carney

In this episode, we consider a creature we often don’t think much about—the snail. And not just snails, but their sex lives. Which, as it turns out, is epic. There is persuasion and subterfuge, spaghetti penises and co-copulation. And this very surprising habit—erm kink—of making tiny arrows (actually!) and stabbing each other with them. Known as a “love dart,” these limestone daggers aren’t just a strange trick of nature—they have a deep evolutionary purpose. Special thanks to Menno Schilthuizen and Aaron Chase.EPISODE CREDITS: Hosted by - Molly WebsterReported by - Molly WebsterProduced by - Mona Madgavkar, Annie McEwen, Molly WebsterSound design contributed by - Mona Madgavkar, Annie McEwenFact-checking by - Diane A. Kellyand Edited by - Alex Neason EPISODE CITATIONS:Videos - A love dart being DARTED! (https://zpr.io/rYhLwXhaxQQP) – Molly has watched this video so many timesArticles - Changes in the reproductive system of the snail Helix aspersa caused by mucus from the love dart. (https://zpr.io/xxjuCcTyiVJV) by Koene JM, Chase R. J Exp Biol. The snail's love-dart delivers mucus to increase paternity. By Chase R, Blanchard KC. Proc Biol Sci. A love-dart at the heart of sexual conflict in snails (https://zpr.io/X2ANHPaEg5sr) by Foote C ** This article has an image of eight different love darts, and it’s what Molly shows to Soren in the episode (this image is one of her favorite research finds!) Books - “Nature’s Nether Regions: What the Sex Lives of Bugs, Birds, and Beasts Tell Us About Evolution, Biodiversity, and Ourselves” (https://zpr.io/ktMvJbZciCdD) by evolutionary biologist Menno Schilthuizen. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In this episode, first aired in 2014, we examine three very different kinds of black boxes—spaces where we know what’s going in, we know what’s coming out, but can’t see what happens in-between. From the darkest parts of metamorphosis to a sixty-year-old secret among magicians, and the nature of consciousness itself, we shine some light on three questions. But for each, we contend with an answerless space, leaving just enough room for the mystery and magic, always wondering what’s inside the Black Box. EPISODE CREDITS: Reported by Tim Howard and Molly WebsterProduced by Tim Howard and Molly Webster EPISODE CITATIONS:Radio Show: ABC's Keep Them Guessing (https://tinyurl.com/9r9zmftr)LATERAL CUTS:Last year we shared a story on our feed about butterfly researcher Dr. Martha Weiss, and how she befriended a little boy on the other side of the world who wanted to do his own caterpillar memory study. Martha’s daughter Annie Rosenthal captured the whole adventure on tape and produced a gorgeous audio feature, “Caterpillar Roadshow,” which was first published in the audio magazine Signal Hill. You can find it on our feed (https://zpr.io/xPdAYXFUMr4s)–or on Signal Hill’s website. (https://zpr.io/a4bjPKeXJQWK) Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Before he was even born, Sarah and Ross Gray knew that their son Thomas wouldn’t live long. But as they let go of him, they made a decision that reverberated through a world that they never bothered to think about. Years later, after a couple of awkward phone calls, they go on a quest and manage to meet the people and places for whom Thomas’ short life was an altogether different kind of gift. We originally made this story back in 2015, but we wanted to play it again because we love that it brings a view of science that is redemptive, tender, and unexpected. Since we first released this episode, Sarah Gray wrote a book called A Life Everlasting (https://zpr.io/GVYisRaqe9d6), it’s a memoir about Thomas that dives into the world of organ donation and medical science. She’s also written a beautiful short story about shame called The Lacemaker Fairy Tale (https://zpr.io/Li5BMtfHmf92). And, right now she’s working on a script for a movie called Raincheck.EPISODE CREDITS:Reported by - Jad Abumradwith help from - Latif NasserLATERAL CUTS - The Cathedral (https://radiolab.org/podcast/cathedral) The Immortal Life of Henrietta Lacks (https://radiolab.org/podcast/the-immortal-life-of-henrietta-lacks) Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In the early 2000s, Sunil Nakrani felt stuck. Back then, websites crashed all the time. When Sunil noticed this, he decided he was going to fix the internet. But after nearly a year of studying the architecture of the web, he was no closer to an answer. In desperation, Sunil sent out a raft of cold emails to engineering professors. He hoped someone, anyone, could help him figure this out. Eventually, he learned that the internet could only be fixed if he paid attention to the humble honeybee. This is the story of the Honeybee Algorithm: How tech used honeybees to build the internet as we know it. Special thanks to John Bartholdi, John Vande Vate, Sammy Ramsey, James Marshall, Steve Strogatz, Duc Pham, and Heiko Hamann. We found out about this story thanks to our friends at AAAS, who run the one and only Golden Goose Awards. The award goes to government funded science that sounds trivial or bizarre, but goes on to change the world. The Honeybee Algorithm won a Golden Goose Award back in 2016 (https://www.goldengooseaward.org/01awardees/honey-bee-algorithm). Thank you to our friends there: Erin Heath, Gwendolyn Bogard, Valeria Sabate, Joanne Padron Carney, and Meredith Asbury. EPISODE CREDITS: Reported by - Latif Nasserwith help from - Maria Paz GutiérrezProduced by - Maria Paz Gutiérrez, Annie McEwen and Pat Waltersand Edited by - Pat Walters EPISODE CITATIONS: Videos - Golden Goose Award video about 2016 winners (https://zpr.io/eXwTJKGL6F8S) Books - The Wisdom of the Hive: The Social Physiology of Honeybee Colonies (https://www.hup.harvard.edu/books/9780674953765) by Thomas D. Seeley (1995, Harvard University Press) Piping Hot Bees & Boisterous Buzz-Runners: 20 Mysteries of Honey Bee Behavior Solved (https://zpr.io/tNDqkw372Rhr) by Thomas D. Seeley And, Paths of Pollen (https://zpr.io/cqRPpAdGRwMi) by Stephen Humphrey. One of our former transcribers who we recently learned had hidden talents far beyond the invaluable work they did for us. This book is only tangentially related to the content in the episode, but super cool in its own right. Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In this episode, we break the thermometer and watch the mercury spill out as we discover that temperature is far stranger than it seems. We first ran this episode in 2021: Five stories that run the gamut from snakes to stars. We start out underwater, with a species of snake that has evolved a devious trick for keeping warm. Then we hear the tale of a young man whose seemingly simple method of warming up might be the very thing making him cold. And Senior Correspondent Molly Webster blows the lid off the idea that 98.6 degrees Fahrenheit is a sound marker of health. Reported by - Lulu Miller and Molly WebsterProduced by - Becca Bressler, Lulu Miller and Molly Websterwith help from - Carin LeongFact-checking by - Emily Krieger Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

One spring evening in 2024, a science journalist named Rachel Gross bombed at karaoke. The culprit was a bleed in a fist-sized clump of neurons tucked down in the back of her brain called the cerebellum. A couple weeks later, her doctors took a bit of it out, assuring her it was just helping her with motor coordination — she might be a bit clumsy for a while, but she’d still be herself. But afterwards, she didn't feel like herself. So she dove into the dusty basement of the brain (and brain science) to figure out why. What Rachel found was a burgeoning new frontier in neuroscience. We learn what singing Shakira on stage has to do with reaching for a cup of coffee — and how the surprising relationship between the two is making us rethink what we think about thinking. Special thanks to Warzone Karaoke at Branded Saloon, Dr. Joanne Loewy and the Singing Together, Measure by Measure choir at the Louis Armstrong Center for Music and Medicine (http://musicandmedicine.org/) at Mount Sinai Union Square, Dag Spicer and the Computer History Museum, Désirée Lie, Mark Gross, Daniel A. Gross, Brittany Aguilar, and, of course, Shakira. EPISODE CREDITS: Reported by - Rachel GrossProduced by - Sindhu GnanasambandanEPISODE CITATIONS: Articles - “Ignoring the cerebellum is hindering progress in neuroscience.” (https://pubmed.ncbi.nlm.nih.gov/39934082/), by Wang et al, 2025 “The cerebellum and cognition.” (https://pubmed.ncbi.nlm.nih.gov/29997061/), by Schmahmann JD. Neurosci Lett. 2019 “How did brains evolve?” (https://pubmed.ncbi.nlm.nih.gov/11805823/), by Barton RA., Nature. 2002 Books - Vagina Obscura (https://www.rachelegross.com/book), by Rachel E. Gross Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Most of us spend some part of our lives feeling bad about ourselves and wanting to feel better. But this preoccupation is a surprisingly new one in the history of the world, and can largely be traced back to one man: a rumpled, convertible-driving California state representative named John Vasconcellos who helped spark a movement that took over schools, board rooms, and social-service offices across America in the 1990s. This week, we look at the rise and fall of the self-esteem movement and ask: is it possible to raise your self-esteem? And is trying to do so even a good idea? Special thanks to big thank you to the University of California, Santa Barbara Library for use of audio material from their Humanistic Psychology Archives and to their staff for helping located so many audio recordings. EPISODE CREDITS: Reported by - Heather Radke and Matt Kielty Produced by - Matt KietlyFlute performance and compositions by - Ben BatchelderVoiceover work by - Dann FinkFact-checking by - Anna Pujol-Mazzini and Angely Mercadoand Edited by - Pat Walters EPISODE CITATIONS: Articles - UCSB Humanistic Psychology Archive (https://zpr.io/HfVjUmvcVevE) Books - Selfie: How We Became So Self-Obsessed and What It's Doing to Us (https://zpr.io/eGRyqz9zNQHu) by Will Storr. Counterpoint, 2018. A Liberating Vision (https://zpr.io/tJn7BR5m84fv) by Vasconcellos, John. Impact Publishers, Inc., 1979 The Therapeutic State (https://zpr.io/tJn7BR5m84fv) by Nolan, James, Jr. NYU Press, 1998 Sign up for our newsletter. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

This episode, first aired in 2019, brings you the story of John Scott, the professional hockey player that every fan loved to hate. A tough guy. A brawler. A goon. But when an impish pundit named Puck Daddy called on fans to vote for Scott to play alongside the world’s greatest players in the NHL All-Star Game, Scott found himself facing off against fans, commentators, and the powers that be. Was this the realization of Scott’s childhood dreams? Or a nightmarish prank gone too far? Today on Radiolab, a goof on a goon turns into a parable of the agony and the ecstasy of the internet, and democracy in the age of Boaty McBoatface. Special thanks to Larry Lynch and Morgan Springer. Check out John Scott's "Dropping the Gloves" podcast (https://www.droppingthegloves.com/) and his book (https://www.simonandschuster.com/books/A-Guy-Like-Me/John-Scott/9781501159657) "A Guy Like Me". EPISODE CREDITS: Reported by - Latif NasserProduced by - Matt Kielty Original music and sound design contributed by -John Dryden, Thee Oh Sees, Weedeater and Bongzilla. Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

When neuroscientist Madeline Lancaster was a brand new postdoc, she accidentally used an expired protein gel in a lab experiment and noticed something weird. The stem cells she was trying to grow in a dish were self-assembling. The result? Madeline was the first person ever to grow what she called a “cerebral organoid,” a tiny, 3D version of a human brain the size of a peppercorn. In about a decade, these mini human brain balls were everywhere. They were revealing bombshell secrets about how our brains develop in the womb, helping treat advanced cancer patients, being implanted into animals, even playing the video game Pong. But what are they? Are these brain balls capable of sensing, feeling, learning, being? Are they tiny, trapped humans? And if they were, how would we know? Special thanks to Lynn Levy, Jason Yamada-Hanff, David Fajgenbaum, Andrew Verstein, Anne Hamilton, Christopher Mason, Madeline Mason-Mariarty, the team at the Boston Museum of Science, and Howard Fine, Stefano Cirigliano, and the team at Weill-Cornell. EPISODE CREDITS: Reported by - Latif Nasserwith help from - Mona MadgavkarProduced by - Annie McEwen, Mona Madgavkar, and Pat Walterswith mixing help from - Jeremy BloomFact-checking by - Natalie Middleton and Rebecca Randand Edited by - Alex Neason and Pat Walters EPISODE CITATIONS: Videos - “Growing Mini Brains to Discover What Makes Us Human,” Madeline Lancaster’s TEDxCERN Talk, Nov 2015 (https://zpr.io/6WP7xfA27auR) Brain cells playing Pong (https://zpr.io/pqgSqguJeAPK) Reuters report on CL1 computer launch in March 2025 (https://zpr.io/cdMf8Yjvayyd) Articles - Madeline Lancaster: The accidental organoid – mini-brains as models for human brain development (https://zpr.io/nnwFwUwnm2p6), MRC Laboratory of Molecular Biology What We Can Learn From Brain Organoids (https://zpr.io/frUfsg4pxKsb), by Carl Zimmer. NYT, November 6, 2025 Ethical Issues Related to Brain Organoid Research (https://zpr.io/qyiATHEhdnSa), by Insoo Hyun et al, Brain Research, 2020 Brain organoids get cancer, too, opening a new frontier in personalized medicine (https://zpr.io/nqMCQ) STAT Profile of Howard Fine and his lab’s glioblastoma research at Weill Cornell Medical Center: By re-creating neural pathway in dish, Stanford Medicine research may speed pain treatment (https://zpr.io/UnegZeQZfqn2) Stanford Medicine profile of Sergiu Pasca’s research on pain in organoids A brief history of organoids (https://zpr.io/waSbUCSrL9va) by Corrò et al, American Journal of Physiology - Cell Physiology, Books - Carl Zimmer Life’s Edge: The Search for What it Means to be Alive (https://carlzimmer.com/books/lifes-edge/) Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

In 1971, a red-headed, tree-loving astronaut named Stu ‘Smokey’ Roosa was asked to take something to the moon with him. Of all things, he chose to take a canister of 500 tree seeds. After orbiting the moon 34 times, the seeds made it back to Earth. NASA decided to plant the seeds all across the country and then… everyone forgot about them. Until one day, a third grader from Indiana stumbled on a tree with a strange plaque: "Moon Tree." This discovery set off a cascading search for all the trees that visited the moon across the United States. Science writer, and our very own factchecker, Natalie Middleton (https://www.nataliemiddleton.org/) tells us the tale. Read Lulu’s remembrance of Alice Wong for Transom.org: 13 questions I’ll never get to ask Alice Wong (https://transom.org/2026/13-questions-ill-never-get-to-ask-alice-wong/). Check out Natalie’s map to find your nearest moon tree on our show page (https://radiolab.org/podcast/the-travelers-how-moon-trees-hide-among-us)! Help us hunt for more moon trees. If you know of an undocumented moon tree, contact Natalie at nataliemiddleton.org. Check out Natalie’s essay on Moon Trees (https://orionmagazine.org/article/moon-tree/) and Space Zinnias (https://orionmagazine.org/article/astronaut-scott-kelly-flower-experiment-space/) in Orion Magazine (https://orionmagazine.org/). Visit NASA’s official Moon Tree Page (https://science.nasa.gov/resource/apollo-moon-trees/) for a list of all the Apollo 14 Moon Trees in the world. To learn more about Stu Roosa or to learn more about acquiring your own half Moon Tree, check out the Moon Tree Foundation (https://www.moontreefoundation.com/), spearheaded by Stu’s daughter, Rosemary Roosa. A reminder that Terrestrials also makes original music! You can find ‘Tangled in the Roots’ and all other music from the show here (https://www.wnycstudios.org/podcasts/radiolab-kids/just-the-songs). EPISODE CREDITS: Terrestrials was created by Lulu Miller with WNYC Studios. This episode was produced by Tanya Chawla and sound-designed by Joe Plourde. Our Executive Producer is Sarah Sandbach. Our team includes Alan Goffinski, Ana González and Mira Burt-Wintonick. Fact checking was by Diane Kelly. Special thanks to Sumanth Prabhaker from Orion magazine, retired NASA Scientist Dr. Dave Williams, Joan Goble, Tre Corely and NASA scientist Dr. Marie Henderson. Our advisors for this show were Ana Luz Porzecanski, Nicole Depalma, Liza Demby and Carly Ciarrocchi. Support for Terrestrials also comes from the Simons Foundation, the Arthur Vining Davis Foundations, and the John Templeton Foundation. Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

After 35, does fertility tank? As she -- and her friends — approached the age of 35, senior correspondent Molly Webster kept hearing a phrase over and over: “fertility cliff.” It was a short-hand term to describe what she was told would happen to her fertility after she turned 35 — that is, it would drop off. Suddenly, sharply, dramatically. And this was well before she was supposed to hit menopause. Intrigued, Molly decided to look into it — what was the truth behind this so-called cliff, and when, if so, would she topple? This story first premiered in “Thirty Something,” a 2018 Radiolab live show that was part of, Gonads, (https://radiolab.org/series/radiolab-presents-gonads)a six-episode audio and live event series all about reproduction and the parts of us that make more of us. The live event was produced by Rachael Cusick and edited by Pat Walters. Special thanks to epidemiologist Lauren Wise, at Boston University. Plus, Emily, Chloe, and Bianca. And of course, Jad Abumrad. If you’re more of a visual person, here are the graphs we explain in the episode, we also include links to the corresponding papers in our Episode Citations Section, below! LINK TO GRAPHS: https://media.wnyc.org/i/1860/1046/c/80/2025/12/FERTILITY_AGE_GRAPHS_1-4.jpg EPISODE CREDITS: Reported by - Molly Webster Produced by - Arianne Wack Fact-checking by - Diane A. Kelly EPISODE CITATIONS: Audio: Gonads (https://radiolab.org/series/radiolab-presents-gonads/) A six-part audio series on reproduction and the parts of us that make more of us The Menopause Mystery (https://radiolab.org/podcast/the-menopause-mystery) One of Radiolab’s most listened-to episodes of 2025! Videos: “Radiolab Presents: Thirty Something” https://youtu.be/LOJVAaSwags?si=czCBraHf1JEqmAQi Research Articles: Graph 1: Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment (https://zpr.io/ft6dqdbkJnTd) Graph 2: Ovarian aging: mechanisms and clinical consequences (https://zpr.io/GrPLebynpvxV) , Brookmans, et al. BUT, the graph was borrowed and actually comes from this 1991 paper, Delaying childbearing: effect of age on fecundity and outcome of pregnancy” (https://zpr.io/whWg2UAZsb6h) Graph 3 and 4: Age and fecundability in a North American preconception cohort study, (https://zpr.io/Rmqry4Kd67hY) Wise et al; Dutch fertility research Further reading: Predicting Fertility, (https://zpr.io/YEdfiYT29rUh): Magazine article on Lauren Wise’s research, Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected]. Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

The standard view of evolution is that living things are shaped by cold-hearted competition. And there is no doubt that today's plants and animals carry the genetic legacy of ancestors who fought fiercely to survive and reproduce. But in this hour that we first broadcast back in 2010, we wonder whether there might also be a logic behind sharing, niceness, kindness ... or even, self-sacrifice. Is altruism an aberration, or just an elaborate guise for sneaky self-interest? Do we really live in a selfish, dog-eat-dog world? Or has evolution carved out a hidden code that rewards genuine cooperation? Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

It’s faster than a speeding bullet. It’s smarter than a polymath genius. It’s everywhere but it’s invisible. It’s artificial intelligence. But what actually is it? Today we ask this simple question and explore why it’s so damn hard to answer. Special thanks to Stephanie Yin and the New York Institute of Go for teaching us the game. Mark, Daria and Levon Hoover Brauner for helping bring NETtalk to life. And a huge thank you to Grant Sanderson for his unending patience explaining the math of neural nets to us. To learn more about how these 'thinking machines' actually think, we highly recommend his wonderful youtube channel 3Blue1Brown ( https://www.youtube.com/watch?v=aircAruvnKk) . EPISODE CREDITS: Reported by - Simon Adler Produced by - Simon Adler Original music from - Simon Adler Sound design contributed by - Simon Adler Fact-checking by - Anna Pujol-Mazzini Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Gordon and Betty

A year ago we brought you a show called Shell Game where a journalist named Evan Ratliff made an AI copy of himself. Now on season 2 of the show, Evan’s using AI to do more than just mimic himself — he’s starting a company staffed entirely by AI agents, and making a podcast about the experience. The show is a smart, funny, and truly bizarre look at what AI can do—and what it can’t. This week we bring you the first episode of Shell Game Season Two, Minimum Viable Company. You can sign up to get the rest of the Shell Game ad-free, and the Shell Game newsletter, at shellgame.co . EPISODE CREDITS: Shell Game Hosted by Evan Ratliff, Produced and edited by Sophie Bridges. Shell Game’s Technical Advisor Matty Bohacek Executive Produced by Samantha Henig, Kate Osborn and Mangesh Hattikudur at Kaleidoscope and Katrina Norvell at IHeart Podcasts. Radiolab portions Hosted by Simon Adler Produced by Mona Madgavkar. Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Our original host Jad Abumrad returns to share a new podcast series he’s just released. It’s all about Fela Kuti, a Nigerian musician who created a genre, then a movement, then tried to use his hypnotic beats to topple a military dictatorship. Jad tells us about the series and why he made it, and we play the episode that, for us at least, gets to the heart of the matter: How exactly does his music work? What actually happens to the people who hear it and how does it move them to action? You can find Jad’s entire nine-part series, Fela Kuti: Fear No Man, on Apple or Spotify, or wherever you get your podcasts. EPISODE CREDITS: Reported by - Jad Abumrad Radiolab portions produced by - Sindhu Gnanasambandan Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Today on the show, we’re bringing you an episode from Our Common Nature (https://link.podtrac.com/v7mx144d), a new podcast series where cellist Yo-Yo Ma and host Ana González travel around the United States to meet people, make music and better understand how culture binds us to nature. The series features a few familiar voices, including Ana González (host) and Alan Goffinski (producer), from our kids podcast, Terrestrials (https://link.podtrac.com/vysacqn1). About the episode: West Virginia is defined by its beauty and its coal, two things that can work against each other. Yo-Yo Ma felt this as soon as stepped foot in its hills.This episode explores how music and poetry help process the emotions of a community besieged with disaster and held together by pride and duty. We travel down the Coal River with third-generation coal miner Chris Saunders, who tells us how coal has saved and threatened his life. Poet Crystal Good shares her poetry, which channels her rage and love. And musician and granddaughter of West Virginia coal miners, Kathy Mattea, explains the beauty of belting out your home state in a chorus. The end of the episode finds host Ana floating down the New River with help from a group of high schoolers and Yo-Yo Ma. Listen to the full series Our Common Nature (https://link.podtrac.com/v7mx144d). Featuring music by Yo-Yo Ma, Dom Flemons, and Kathy Mattea and poetry by Crystal Good. EPISODE CREDITS: Radiolab Bits Produced - Anisa Vietze (Radiolab bits) Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Qasem Waleed is a 28-year-old physicist who has lived in Gaza his whole life. In 2024, he joined a chorus of Palestinians sharing videos and pictures and writing about the chaos and violence they were living through, as Israel’s military bombardment devastated their lives. But Qasem was trying to describe his reality through the lens of the most notoriously confusing and inscrutable field of science ever, quantum mechanics. We talked to him, from a cafe near the Al-Mawasi section of Gaza, to find out why. And over the course of several conversations, he told us how this reality-breaking corner of science has helped him survive. And how such unspeakable violence actually let him understand, in a visceral way, quantum mechanics’ most counter-intuitive ideas. Special thanks to Katya Rogers, Karim Kattan, Allan Adams, Sarah Qari, Soren Wheeler, and Pat Walters EPISODE CREDITS: Reported by - Lulu Miller Produced by - Jessica Yung with mixing help from - Jeremy Bloom Fact-checking by - Emily Krieger and Edited by - Alex Neason EPISODE CITATIONS: Videos - A Brief History of Quantum Mechanics with Sean Carroll, The Royal Institution ( https://www.youtube.com/watch?v=5hVmeOCJjOU ) Introduction to Superposition, with MIT’s Allan Adams ( https://www.youtube.com/watch?v=lZ3bPUKo5zc ) The Quantum Wavefunction, Explained ( https://www.youtube.com/watch?v=sOI4DlWQ_1w ) Articles - Read a selection of Qasem’s published essays about his life in Gaza and the quantum world: I am stuck in a box like Schrodinger’s in Gaza ( https://zpr.io/ALDVi9E5bRt8 ) Israel has turned Gaza’s summer into a weapon ( https://zpr.io/YS4WK4hVQC5T ) The Physics of Death in Gaza ( https://zpr.io/hxsgxicVqPAd ) Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

When we think of China today, we think of a technological superpower. From Huawei and 5G to TikTok and viral social media, China is stride for stride with the United States in the world of computing. However, China’s technological renaissance almost didn’t happen. And for one very basic reason: the Chinese language, with its 70,000 plus characters, couldn’t fit on a keyboard. Today, we tell the story of Professor Wang Yongmin, a hard-headed computer programmer who solved this puzzle and laid the foundation for the China we know today. Special thanks to Martin Howard. You can view his renowned collection of typewriters at: antiquetypewriters.com . EPISODE CREDITS: Reported by - Simon Adler Produced by - Simon Adler Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Signup (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

A call to oceanographer Edie Widder about a fish with a very odd immune system quickly becomes something else: a dive into the deep sea, into a world of brilliant light. But down there, the light doesn’t behave like light -- it sparkles and glows, but also drips, squirts, and dribbles. Today, find out how creatures make the light and how they use it, from hunting and hiding to maybe even … talking. And hear about a series of mysterious moments where Edie goes from studying the creatures to becoming one of them. EPISODE CREDITS: Hosted by - Molly Webster Reported by - Molly Webster Produced by - Maria Paz Gutierrez with help from - Molly Webster Fact-checking by - Diane A. Kelly LATERAL CUTS (Other Radiolab episodes you may like): Octomom - https://radiolab.org/podcast/octomom The Darkest Dark - https://radiolab.org/podcast/the-darkest-dark EPISODE CITATIONS: Documentary - Coming soon, there’ll be a new doc about Edie’s life and work studying bioluminescence in deep sea creatures. According to Edie, “ A Life Illuminated ”, contains some of the best deep sea bioluminescence footage ever recorded. It’s from our friends at Sandbox Films, and director Tasha Van Zandt. https://www.sandboxfilms.org/films/a-life-illuminated/ Books - Edie Widder wrote a memoir! Go read, “Below the Edge of Darkness: A Memoir of Exploring Light and Life in the Deep Sea”.https://www.penguinrandomhouse.com/books/564185/below-the-edge-of-darkness-by-edith-widder-phd/ Videos - It’s not in the episode, but a few years back, Edie’s fame reached new heights when she captured footage of a never-before-seen Giant Squid … here’s the story, and video. https://www.youtube.com/watch?v=krDdv9KLmuM Articles - A look at some glowing shrimps. https://zpr.io/3jyHWi7VFBw5 A photo gallery of different types of deep sea glow, from different types of deep sea creatures, including one of counterillumination, which Edie talks about in the episode. https://zpr.io/hdFFsArGjhau Sign up for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Love it or hate it, the freedom to say obnoxious and subversive things is the quintessence of what makes America America. But our say-almost-anything approach to free speech is actually relatively recent, and you can trace it back to one guy: a Supreme Court justice named Oliver Wendell Holmes. Even weirder, you can trace it back to one seemingly ordinary eight-month period in Holmes’s life when he seems to have done a logical U-turn on what should be say-able. Why he changed his mind during those eight months is one of the greatest mysteries in the history of the Supreme Court. (Spoiler: the answer involves anarchists, a house of truth, and a cry for help from a dear friend.) Join us in an episode we originally released in 2021, as we investigate why he changed his mind, how that made the country change its mind, and whether it’s now time to change our minds again. Special thanks to Jenny Lawton, Soren Shade, Kelsey Padgett, Mahyad Tousi and Soroush Vosughi. LATERAL CUTS: Content Warning Facebook Supreme Court The Trust Engineers EPISODE CREDITS: Reported by - Latif Nasser Produced by - Sarah Qari with help from - Anisa Vietze Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

Over the past five years TikTok has radically changed the online world. But trust us when we say, it’s not how you’d expect. Today we continue our yearslong exploration of what you can and can’t post online. We look at how Facebook’s approach to free speech has evolved since Trump’s victory. How TikTok upended everything we see. And what all this means for the future of our political and digital lives. Special thanks to Kate Klonick EPISODE CREDITS: Reported by - Simon Adler Produced by - Simon Adler Original music from - Simon Adler with mixing help from - Jeremy Bloome Fact-checking by - Anna Pujol-Mazzini Lateral Cuts: The Trust Engineers Facebook’s Supreme Court Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)! Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today. Follow our show on Instagram , Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected] . Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.