Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias , focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) , discussing the role of BCR-ABL in CML and the implications of smudge cells and monoclonal B-cell proliferation in CLL . Our conversation covers key diagnostic tools such as PCR, flow cytometry, and blood smear findings , as well as cutting-edge treatment options like tyrosine kinase inhibitors (TKIs) for CML and targeted monoclonal antibody therapy for CLL . We also discuss disease progression, complications like Richter transformation, and indications for therapy in asymptomatic patients. This high-yield episode is perfect for both exam prep and clinical application—enjoy and support us below! Support the show
