Mini Mikkipedia - GLP-1s and the ADHD Brain

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In this Mini-Mikkipedia episode, Mikki explores the emerging intersection between GLP-1 medications and ADHD, particularly around appetite, impulsivity, reward-seeking behaviour, and food noise. While there is currently no direct evidence that GLP-1s improve attention or focus, there is growing interest in how these medications act on brain reward circuits involved in compulsive eating, cue reactivity, alcohol intake, and other hedonic behaviours. Mikki breaks down why ADHD is more than an attention issue, explaining its links with dopamine regulation, obesity risk, binge eating, and emotional eating patterns. She also discusses why GLP-1s may be helpful for some adults with ADHD, while potentially creating issues such as low mood, flatness, reduced motivation, or under-fuelling in others. A nuanced one — less “magic bullet,” more “know the machinery.”

Highlights / Topics Covered:

• Why ADHD is closely tied to dopamine, reward-seeking, impulsivity, and eating behaviour
• The relationship between ADHD, obesity, binge eating, and “food addiction” patterns
• How GLP-1 medications may influence reward circuits, food noise, cue reactivity, and compulsive eating
• Why GLP-1s could be helpful for some people with ADHD but may worsen flatness, motivation, or mood in others
• Practical considerations around nutrition, protein intake, stimulant medications, appetite suppression, and monitoring

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