Priscilla Chan and Mark Zuckerberg: Frontier AI + Virtual Biology To Solve All Diseases

Today’s guests are Priscilla Chan and Mark Zuckerberg, co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE, rbio1, VariantFormer, and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases. Chapters 00:00:00 Introduction and CZI's 10-Year Anniversary 00:00:56 Learning from Bill Gates 00:04:05 Science vs Translation 00:10:45 The Power of Physical Proximity in Science 00:13:55 Building the Virtual Cell: From Data to Models 00:15:51 Microscopes, Imaging, and Converting Atoms to Bits 00:23:18 AI Meets Biology: The Frontier Lab Concept 00:27:25 How Models Can Enable More Ambitious Research 00:30:15 Precision Medicine and Clinical Impact 00:45:17 The Virtual Immune System and Cellular Engineering 00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease 00:28:45 Joining Forces with Evolutionary Scale