Could CAR-T therapy transform autoimmune disease?

An experimental treatment to “reset” the immune systems of people with autoimmune disease is showing transformative results in early trials.

James visits the NIHR Clinical Research Facility in Manchester to meet Kathy. She was diagnosed with lupus just after the birth of her baby and in 2024 became the first person in the UK to try CAR-T therapy as part of a clinical trial. How is she feeling now?

We’ll also hear from Kathy’s rheumatologist Professor Ben Parker, who led the trial Kathy took part in and explains how the therapy works, the astonishing early results - and whether the effects on the immune system are long lasting.

Also this week, James visits the London School of Hygiene and Tropical Medicine to meet some lab-grown British mosquitoes and find out whether they’re out to get us for longer periods of the year and how worried we should be about the threat of disease, with medical entomologist Dr Mojca Kristan and virologist Professor Roger Hewson.

And we look at the latest online trend of “spermmaxxing” with urologist Professor Vaibhav Modgil. Why are men trying to optimise their sperm by dipping their testicles in iced water and abstaining from porn - and is there any evidence for these tactics?

Presenter: James Gallagher Producer: Gerry Holt Editor: Ilan Goodman Production coordinator: Stu Laws Sound engineer: Mary Stone