Inside Edition for Wednesday Oct 21, 2026

There is big reaction to actress Christina Applegate’s bombshell news that she was misdiagnosed with MS, which she spent the last five years being treated for. Now women across America are coming forward, wondering if they too have been misdiagnosed. As Jim Moret reports, it’s causing a lot of anxiety. And it’s a mother-daughter fight that’s now a political hot potato. Ohio Republican gubernatorial candidate Vivek Ramaswamy is raising eyebrows with his new campaign ad. Many believe he crossed the line by pitting his opponent against her estranged mother. Family members, they say, should be off limits. Plus, giant inflatable pumpkins are the most popular Halloween decorations this year. But across the country, high winds have been carrying them away, leading to chaos on the streets. Ann Mercogliano has what you need to know to make sure your pumpkin doesn’t go flying. And it’s a national phenomenon, with millions flocking to movie theaters, not to see the latest Marvel action movie, but a three-hour documentary. Alison Hall tells us what all the fuss is about.