Podcast 631: UK COVID-19 Mutation

Contributor: Gretchen Hinson, MD

Educational Pearls:

• Viruses mutate frequently and a new variant of COVID has been found in the United Kingdom.
• Mutations typically occur due to transcription errors during virus replication leading to slight changes in the virus which can alter its virulence, and this UK mutation has shown more infectivity.
• The UK variant was first identified on 9/20/20 and sequenced in October
• The variant has a mutation of the spike protein with increased receptor binding capacity, making it more efficient at infecting cells
• Children seem to be more susceptible to this variant as compared to the prior COVID strains.

References

1) Tang JW, Tambyah PA, Hui DS. Emergence of a new SARS-CoV-2 variant in the UK. J Infect. 2020 Dec 28:S0163-4453(20)30786-6. doi: 10.1016/j.jinf.2020.12.024. Epub ahead of print. PMID: 33383088.

Summarized by Jackson Roos, MS4 | Edited by Erik Verzemnieks, MD

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