📝 “What is the Recurrence Rate of Adenoid Cystic Carcinoma in the Oral Cavity?”

8.13.24

Quick Review #202 - #pathology #oralpathology #doctorgallagher #oralsurgery #oralsurgeon #dentist #dentistry #dental #adenocarcinoma #adenoidcysticadenocarcinoma

Adenoid cystic carcinoma (ACC) of the oral cavity is known for its propensity for local recurrence and distant metastasis, particularly to the lungs.

The recurrence rates for ACC can vary significantly depending on several factors, including the presence or absence of perineural invasion (PNI).

1. Without Perineural Invasion (PNI):

• The recurrence rate for ACC without perineural invasion tends to be lower, although the exact percentage can vary depending on the study. On average, the local recurrence rate in cases without PNI is around 20-30% over a 5 to 10-year period.

2. With Perineural Invasion (PNI):

• ACC with perineural invasion has a significantly higher recurrence rate due to the tumor’s ability to spread along nerve pathways. The recurrence rate in cases with PNI can range from 50-70% over a similar 5 to 10-year period, making PNI a poor prognostic indicator.

These figures highlight the aggressive nature of ACC, particularly when PNI is present, emphasizing the importance of early detection and comprehensive treatment to minimize the risk of recurrence.

References:

1. García-Sevilla, M., Moreta-Martínez, R., García-Mato, D., Arenas de Frutos, G., Ochanindiano, S., Navarro-Cuéllar, C., Sanjuán de Moreta, G., & Pascau, J. (2022). Surgical navigation, augmented reality, and 3D printing for hard palate adenoid cystic carcinoma en-bloc resection: Case report and literature review. Frontiers in Oncology, 11, Article 741191. https://lnkd.in/ea4uehYm

2. Fordice, J., Kershaw, C., El-Naggar, A., & Goepfert, H. (1999). Adenoid cystic carcinoma of the head and neck: Predictors of morbidity and mortality. Archives of Otolaryngology–Head & Neck Surgery, 125(2), 149-152. https://lnkd.in/eh7qJs_S

3. Kokemueller, H., Eckardt, A., Brachvogel, P., & Hausamen, J. E. (2004). Adenoid cystic carcinoma of the head and neck—A 20 years experience. International Journal of Oral and Maxillofacial Surgery, 33(1), 25-31. https://lnkd.in/e8RcfuSZ

4. Sung, M. W., Kim, K. H., Kim, J. W., Min, Y. G., Seong, W. J., & Park, S. W. (2003). Clinicopathologic predictors and impact of perineural invasion in adenoid cystic carcinoma of the head and neck. Head & Neck, 25(7), 618-625. https://lnkd.in/egVmfnWj

5. ChatGPT. 2024.

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