📝 “What are the Dental Anomalies of Cleidocranial Dysplasia, Down Syndrome, and Gardner Syndrome?”

8.1.24 Quick Review #193 - #pathology #oralpathology #doctorgallagher #oralsurgery #oralsurgeon #dentist #dentistry #dental #dentalanomaly #downsyndrome #cleidocranialdysplasia #gardnersyndrome 1 - Cleidocranial dysplasia (CCD) is a genetic disorder resulting from mutations in the RUNX2 gene, affecting bone and dental development. • Multiple Impacted Teeth: Due to delayed eruption, many teeth remain unerupted and impacted within the jawbone. • Supernumerary Teeth: Extra teeth beyond the normal complement, complicating eruption and alignment. • Retention of Primary Teeth: Primary teeth are often retained longer due to delayed eruption of permanent teeth. • Abnormal Tooth Shape and Position: Misaligned, malformed, and irregularly positioned teeth. • Delayed Eruption: Significant delays in both primary and permanent teeth eruption. 2 - Down syndrome (Trisomy 21), caused by an extra chromosome 21, leads to various developmental anomalies, including significant dental manifestations: • Multiple Impacted Teeth: Common due to delayed eruption. • Hypodontia: Absence of certain teeth, particularly lateral incisors and second premolars. • Microdontia: Smaller than normal teeth, affecting function and aesthetics. • Periodontal Disease: Higher susceptibility to gum disease, leading to early tooth loss. • Malocclusion: Misalignment of teeth and jaws, resulting in functional and aesthetic concerns. • Delayed Eruption: Delays in both primary and permanent teeth eruption. 3 - Gardner syndrome is a genetic disorder associated with mutations in the APC gene, leading to anomalies in dental structures: • Multiple Impacted Teeth: Delayed eruption results in multiple unerupted teeth. • Supernumerary Teeth: Extra teeth beyond the normal count, complicating dental alignment. • Odontomas: Benign tumors related to tooth development, obstructing normal eruption. • Jaw Osteomas: Benign bone growths in the jaw, interfering with dental development and tooth positioning. References: 1. Pereira, D. L., Carvalho, P. A., Achatz, M. I. W., Rocha, A. C., Torrezan, G. T., & Alves, F. A. (2016). Oral and maxillofacial considerations in Gardner’s syndrome: A report of two cases. ecancermedicalscience, 10, 623. https://lnkd.in/dTrsXkjj 2. Cooper, S. C., Flaitz, C. M., Johnston, D. A., Lee, B., & Hecht, J. T. (2001). A natural history of cleidocranial dysplasia. American Journal of Medical Genetics Part A, 104(1), 1-16. https://lnkd.in/d2gZPsXb 3. Desai, S. S. (1997). Down syndrome: A review of the literature. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 84(3), 279-285. https://lnkd.in/dqdZASRR 4. Gorlin, R. J., Cohen Jr, M. M., & Levin, L. S. (1990). Syndromes of the head and neck. Oxford University Press. https://lnkd.in/dvSAaMgJ 5. ChatGPT. 2024. #podcast #podcasts #dentalpodcast #dentalpodcasts #doctorgallagherpodcast #doctorgallagherspodcast #doctor #dentistry #oralsurgery #dental #viral #dentalschool #dentalstudent #omfs #surgeon #doctorlife #dentistlife #residency #oralsurgeon #dentist #doctorgallagher