Episode October 10, 2025 14 min 42s

ADVANCES IN PHOTODYNAMIC THERAPY RESEARCH

From Dentistry Made Simple Dentistry Made Simple

An extensive overview of Photodynamic Therapy (PDT), a non-invasive treatment utilizing photosensitizers (PSs), light, and oxygen to generate Reactive Oxygen Species (ROS) for localized therapeutic action, primarily against cancer and microbial infections. The first chapter discusses strategies for improving PDT outcomes, focusing on optimizing light sources, dosimetry, and the use of PS fluorescence for photodiagnosis. The second chapter focuses on the application of PDT in dentistry, including its use in treating oral diseases like periodontitis, oral malignancies, and infections. Finally, the third chapter highlights the therapeutic potential of Conjugated Polymer Nanoparticles (CPNs) as advanced PSs for PDT and Photodynamic Inactivation (PDI), detailing their exceptional light-harvesting capabilities, enhanced efficacy, and the challenges for their preclinical and clinical development.

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