In this episode of American Glutton, Ethan Suplee welcomes back Dr. Christopher McGowan to discuss the science behind weight loss, GLP-1 medications, and the body's resistance to maintaining weight loss. They explore the role of hunger hormones, the risks of rapid weight cycling, and groundbreaking new medical procedures that can help control appetite. Dr. McGowan shares insights on endoscopic techniques, including ghrelin-reducing procedures, and the future of weight loss interventions. SHOW HIGHLIGHTS 00:00 – Welcome Back, Dr. Christopher McGowan 00:11 – The Science of Weight Regain 02:07 – The Struggle of Long-Term Weight Loss 04:32 – What Comes After GLP-1s? 06:42 – Compounded Medications and Market Trends 12:49 – Risks of Yo-Yo Dieting and Muscle Loss 17:28 – Ghrelin: The Hunger Hormone Explained 20:57 – New Endoscopic Procedures for Appetite Control 26:49 – Comparing Surgical and Non-Surgical Options 37:34 – The Future of Weight Loss Interventions 58:15 – Closing Thoughts and Final Takeaways Hosted on Acast. See acast.com/privacy for more information.