Featuring an interview with Dr Ramez Eskander, including the following topics:
- Overview of antibody-drug conjugates (ADCs) and their role in the management of gynecologic cancers; considerations in sequencing (0:00)
- Choosing between FRɑ- and HER2-directed ADCs for dually eligible patients; role of antigenic target in predicting efficacy benefit of ADCs (7:53)
- Comparative efficacy and safety of ADCs and conventional chemotherapy (12:58)
- Current and investigational targets of ADCs in gynecologic cancers (17:14)
- Current research surrounding raludotatug deruxtecan (R-DXd) and its potential role in clinical practice (21:56)
- Safety and tolerability profiles of ADCs, including R-DXd, and potential mitigation strategies (27:36)
- Overview of available TROP2-directed ADCs for gynecologic cancers, including key clinical data (33:34)
- Evolving use of TROP2-directed ADCs for gynecologic cancers in clinical trials (39:05)
- Oral mucositis/stomatitis associated with TROP2-directed ADCs and potential mitigation strategies (44:38)
CME information and select publications
