Hacking Nootropic tolerance, a drug that makes coffee INTENSE & more

The year’s most BORING month is upon us--February. We get the crappiest winter weather, but without the “new year, new you” vibes of January, and the warming climes of March remain many moons away. So what else is there to do than Biohack?

And I’m here to help, answering your Biohacking and lifehacking questions in the Q&A podcasts below.

Disclaimer

What you find on this website is NOT medical advice. I’m not a doctor. I’m just an experienced, unlicensed self-experimenter practicing free speech by talking about my own extensive experiences and my interpretations of published science. Please see my guide on How to Biohack Smart and Safe. You should consult a doctor about any Biohacking you’re doing and, ideally, also get a second opinion.

#4 Questions

Q

Do you guys feel you develop a tolerance to these drugs?

A

Yes, you will, over time, develop a tolerance to whatever smart drug you are taking. The racetams have a less pronounced tolerance curve, which makes them a more sustainable cognitive enhancement option.

Modafinil, in contrast, has a steep tolerance curve.

So employ cycling strategies: 1) Take different Nootropics on alternating days, 2) Take weekends off Nootropics, 3) Buy your Nootropics in 1-month supplies and go off them for 3 months after exhausting your supply

Q

Hey Johnathan, i was just wondering what your thoughts are on the use of memantine for resetting caffeine tolerance in young healthy individuals. Thanks!

A

More about Memantine

Evidence for thishttps://redd.it/483ldqhttp://www.longecity.org/forum/topic/29900-memantine-combined-with-drugssupplements-other-than-psychostims/https://www.ncbi.nlm.nih.gov/pubmed/15187578

Recommendation: Quit coffee (or taper off while switching to de-caff and start your mornings drinking Rhodiola tea)

Q

Do you know of any natural alternatives to the racetamswill alpha gpc or niacin do the same trick etc?i need something that’s natural that will get me focused and concentrating and able to remmeber when i study without any side effects.no i havent tried any racetamsbecause ive read up that they have many side effectsand from what you say they only boost ones focus and memory for about 4 to 6 hrsDo let me know if theres supplemnts, minaerals or vitamins that are naturaland can help study focus and memorization naturally with virtually no side effects

A

Recommendations

The Adaptogens - Nootropics comparison

Rhodiola

Bacopa

Q

I just jumped the gun and bought Aniracetam without seeking proper advice.My main goal is to increase focus, work rate and memory.I have a very short attention span at the moment.I get side tracked and when i read, i tend to go off in a tangent thinking about the last line i just read rather than reading the book.Starting to do silly stuff like putting stuff in the fridge when its supposed to be in cupboard etc. Silly but they all add up.Any advice?

A

More about Aniracetam

Recommendations

Dual N-Back brain training

Meditation - The Blue Sky Meditation Protocol

Q

This all has to do with Bromantane, I promise! lolBeen watching your videos almost religiously and have learned a massive amount of information from you as well as reddit and NIH documents etc etc Loving bromantane almost beyond beyond the point of words.Anything out there like nsi that can change the physical structure of the brain?

First of all I should apologize for not responding sooner as I did get your message yesterday and didn’t respond out of my being nervous. I have/had brain damage caused by datura poisoning from when I was 17 which eventually led me to develop several other very serious mental illnesses.Here’s the tricky part that makes me sound a bit narcissistic to some people. The Jimson weed did give me a pretty specific type of brain damage which didn’t cause me to lose my intellect but seemed to have increased it but at the cost of most of my executive function and social function. I was obsessed with medical knowledge before to the point that I was buying a new DSVM every year in my teens which looking back was kind of weird but afterward I am much worse. Much much worse. I’ve lost two wives to being a total psychological nightmare to some people because of my very eccentric nature.

That being said rain man wants pussy and cars too!

How to get rid of mental illness?

Ya! That’s the bold question I asked myself and took on directly.

So far I’ve slowly made my way back to reality with the help of some extremely rare stuff as well as some of the basic nootropics.I watch your show because you like details. I love details.I started looking at the functions of piracitam years ago and slowly read my way through Russian medicine and have decided those cats have it figured out in the world of neuropsychology and America is just lost.

Long story short I “narrowed it down” to a shorter list of very special things to do in order.

Stop taking anything at all for 30 days.Fast for 48 hours at the end of that 30 day periodAt the end of the fast and a good nights rest get up and begin the paleo diet.Then after a month on the paleo diet I started a regimen that I designed of racetams and nootropics and peptides to literally get rid of my specific illness.

I started with a 2 gram dose of centrophenoxineAnd then continued taking up to 1 gram a day split into 2 dosesAfter 30 days of this I switched to:Alpha Gpc (high dose)phenylpiracitam 100 mg 2x daily)Oxyracitam (750 mg 2x daily)Aniracitam (750 mg 2x daily)Colouracetam (20mg 3x daily)Fasoracetam (40 mg 1x daily)phenibut (800 mg)Theanine (600 mg)While cycling phenibut here and there and also cycling faso and colour and Sulbutiamine so I don’t alter the outcome our burn out my receptors.

After weaning off of that very slowly over a 6 month period of time i began Na Semax-A with bromantane.

I was smart but was very spaced out and very depressed and very scar