Podcasts//The Human Upgrade: Biohacking for Longevity & Performance
The Human Upgrade: Biohacking for Longevity & Performance

The Human Upgrade: Biohacking for Longevity & Performance

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For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.

Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.

This isn’t just self-improvement - it’s human enhancement backed by data.

Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.

Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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Episodios25
Biohacking News Weekly Update : 1388

Biohacking News Weekly Update : 1388

Dec 26, 2025·

This episode covers: • Trump Drug Pricing Deals and Access to Longevity Medications New drug-pricing agreements announced under President Donald Trump aim to lower the cost of high-priced prescription drugs through...

How to Get and Stay Sober in 2026 (The Biohacker’s Guide) | Luke Storey  : 1386

How to Get and Stay Sober in 2026 (The Biohacker’s Guide) | Luke Storey : 1386

Dec 25, 2025·

The holidays are when drinking quietly ramps up for a lot of people. More parties, more stress, more excuses, and habits that feel temporary but often aren’t. This episode is for anyone reflecting on their relationship...

What it takes to be “Young Forever!” | Mark Hyman : 1385

What it takes to be “Young Forever!” | Mark Hyman : 1385

Dec 23, 2025·

Most conversations about longevity focus on tactics. This episode breaks down the biology underneath them. You’ll hear a systems level analysis of how insulin signaling, mTOR, mitochondrial function, inflammation, and...

I Tried $50 Brain Boosting Powder : 1384

I Tried $50 Brain Boosting Powder : 1384

Dec 21, 2025·

Try LMNT and get a FREE gift: In this video, Dave Asprey exposes the hidden reason why people lose muscle tone and mental sharpness as early as their 30s… and reveals the simplest, cheapest powder to reverse the...

Biohacking News Weekly Update : 1383

Biohacking News Weekly Update : 1383

Dec 19, 2025·

This episode covers: • FDA Loosening Supplement Warning Labels The FDA is considering a rule change that would allow supplement companies to include the DSHEA disclaimer only once per package rather than next to every...

The Science of Erotic Altered States | Biohacking Sex : 1382

The Science of Erotic Altered States | Biohacking Sex : 1382

Dec 18, 2025·

This episode explores how intimacy, desire, and erotic states function as powerful tools for healing, nervous system regulation, and personal transformation. You’ll learn why certain forms of conscious erotic play...

Biohacking Fertility for Men and Women at Any Age : 1381

Biohacking Fertility for Men and Women at Any Age : 1381

Dec 16, 2025·

This episode lays out the blueprint for having healthier children later in life by treating preconception as the most important window for human health. You’ll learn why fertility is not just about getting pregnant, but...

Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380

Your Brain Has A Sleep Switch (Do THIS To Turn It On) : 1380

Dec 14, 2025·

Try TrueDark Glasses: Kill your zombie cells with: Your brain has a built-in switch that controls deep sleep but for most people, it’s turned off. In this video, Dave Asprey exposes the hidden factors blocking your deep...

The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379

The One Thing Everyone Thinks They Can’t Afford… Until They Try It : 1379

Dec 12, 2025·

If you want more time, better energy, and a calmer mind, this episode gives you a blueprint for achieving it. Host Dave Asprey talks with entrepreneur Jonathan Swanson, who explains how delegation functions as a...

How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378

How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378

Dec 11, 2025·

Your jaw influences far more than your face. This episode shows you how jaw strength shapes cognition, posture, airway health, sleep, metabolism, and overall human performance. You will learn how targeted jaw training...

I Tried At-Home Ultrasound for My Brain   : 1377

I Tried At-Home Ultrasound for My Brain : 1377

Dec 9, 2025·

Most people stay locked in a constant sympathetic state without realizing it, which drains focus, sleep quality, emotional balance, and long-term resilience. This episode gives you a science backed path to retrain your...

What If You Stop Eating For 72 Hours? : 1375

What If You Stop Eating For 72 Hours? : 1375

Dec 7, 2025·

Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging? In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why...

The Real Reason Your Face Is Aging So Fast  : 1376

The Real Reason Your Face Is Aging So Fast : 1376

Dec 5, 2025·

Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen...

Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374

Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374

Dec 4, 2025·

If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave...

The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools  : 1373

The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools : 1373

Dec 2, 2025·

This episode shows you how light, vibration, and frequency-based technology can shift your brain state in minutes, unlock deep neuroplasticity, release stored trauma, and create coherence that normally takes years of...

How I Lost 100 Pounds By Drinking Butter Coffee : 1371

How I Lost 100 Pounds By Drinking Butter Coffee : 1371

Nov 30, 2025·

In 1999, a Silicon Valley millionaire on the brink of collapse took one mysterious sip atop a frozen Tibetan mountain - and everything changed. That moment sparked a global movement, rewrote the rules of fat and energy...

Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks  : 1372

Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks : 1372

Nov 28, 2025·

Most people think you need sweat, strain, or long workouts to upgrade circulation, metabolism, and energy. What if your body could unlock all of that while you stand still? This episode reveals how to get a full body...

These Secret Compounds Help Injuries Recover 2-3x Faster : 1370

These Secret Compounds Help Injuries Recover 2-3x Faster : 1370

Nov 27, 2025·

Prepare to rethink surgery, healing, anesthesia, and recovery. This episode gives you a complete, high-performance playbook for surgical preparation and accelerated healing, built on biohacking, functional medicine...

Why Breathwork Feels Like a Euphoric Drug | Biohacker Tips : 1369

Why Breathwork Feels Like a Euphoric Drug | Biohacker Tips : 1369

Nov 25, 2025·

Breathwork is one of the most powerful tools in biohacking, yet most people only experience the surface level techniques. When you use it the right way, breathwork can upgrade your brain, strengthen your nervous system...

Dead Water Is Making You Sick! (Biohacking Bonus Episode) : 1368

Dead Water Is Making You Sick! (Biohacking Bonus Episode) : 1368

Nov 24, 2025·

Here’s the hidden story behind why you can chug “pure” water all day and still feel foggy, drained, and oddly thirsty: most of what we drink is missing something essential. In this video you’ll learn what “dead water”...

10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

Nov 21, 2025·

This episode covers: • Nano CBD Pain Relief Without Cognitive Side Effects A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or...

The Methylene Blue Episode | Solo Biohacking Masterclass  : 1366

The Methylene Blue Episode | Solo Biohacking Masterclass : 1366

Nov 20, 2025·

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo...

The Tiny Implant Replacing Life-Changing Drugs | Biohacking Tools : 1365

The Tiny Implant Replacing Life-Changing Drugs | Biohacking Tools : 1365

Nov 18, 2025·

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulation could redefine human performance, longevity, and brain...

The Boring Secret Behind Celebrities Who Don’t Age : 1364

The Boring Secret Behind Celebrities Who Don’t Age : 1364

Nov 16, 2025·

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young? Scientists have discovered a remarkable connection between an ancient...

Biohacking News Weekly Update : 1363

Biohacking News Weekly Update : 1363

Nov 14, 2025·

This episode covers: • Cocoa Extract Cuts Heart Deaths A massive COSMOS trial found that older adults taking high flavanol cocoa extract daily saw a 27 percent reduction in cardiovascular deaths along with drops in...

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