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Latent Space: The AI Engineer Podcast
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Latent Space: The AI Engineer Podcast

Byswyx + Alessio

The podcast by and for AI Engineers! In 2024, over 2 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space

228 Episodes•1 Subscribers•0 Total Listens

Episode Playlist

50 Episodes
🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White
Jan 28, 2026•1:13:56

🔬 Automating Science: World Models, Scientific Taste, Agent Loops — Andrew White

Video
The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI
Feb 6, 2026•1:08:01

The First Mechanistic Interpretability Frontier Lab — Myra Deng & Mark Bissell of Goodfire AI

🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery
Feb 11, 2026•1:21:07

🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

Video
Owning the AI Pareto Frontier — Jeff Dean
Feb 12, 2026•1:23:31

Owning the AI Pareto Frontier — Jeff Dean

Video
Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z
Feb 19, 2026•55:18

Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z

Video
⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data
Feb 23, 2026•26:12

⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

Video
Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis
Feb 24, 2026•2:04:13

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

Video
🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI
Feb 25, 2026•33:56

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka
Feb 26, 2026•52:17

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity
Feb 27, 2026•56:14

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

Video
Every Agent Needs a Box — Aaron Levie, Box
Mar 4, 2026•1:16:58

Every Agent Needs a Box — Aaron Levie, Box

Video
Cursor's Third Era: Cloud Agents
Mar 5, 2026•1:06:39

Cursor's Third Era: Cloud Agents

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)
Mar 10, 2026•1:23:37

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

Video
Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer
Mar 12, 2026•1:00:32

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

Video
Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop
Mar 17, 2026•1:26:59

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

Video
Dreamer: the Personal Agent OS — David Singleton
Mar 20, 2026•1:03:35

Dreamer: the Personal Agent OS — David Singleton

Video
🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik
Mar 24, 2026•35:14

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

Video
Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample
Mar 30, 2026•48:48

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

Video
Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun
Apr 2, 2026•1:06:47

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

Video
Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"
Apr 3, 2026•1:16:20

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

Video
Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony
Apr 7, 2026•1:12:43

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

Video
Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion
Apr 14, 2026•1:17:17

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

Video
🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik
Apr 20, 2026•1:25:21

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

Video
Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO
Apr 22, 2026•1:12:25

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

Video
AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)
Apr 23, 2026•54:52

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition
Apr 27, 2026•1:12:21

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

Video
🔬Doing Vibe Physics — Alex Lupsasca, OpenAI
May 5, 2026•1:31:51

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

Video
AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge
May 14, 2026•1:05:20

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

Video
The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion
May 18, 2026•1:59:28

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

Railway: The Agent-Native Cloud — Jake Cooper
May 20, 2026•1:28:34

Railway: The Agent-Native Cloud — Jake Cooper

Video
Giving Agents Computers — Ivan Burazin, Daytona
May 21, 2026•1:10:27

Giving Agents Computers — Ivan Burazin, Daytona

Video
🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub
May 27, 2026•1:10:12

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray
May 28, 2026•1:08:02

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

Video
Why Video Agent models are next — Ethan He, xAI Grok Imagine
Jun 1, 2026•1:43:26

Why Video Agent models are next — Ethan He, xAI Grok Imagine

Video
GitHub's plan for Agents — Kyle Daigle, GitHub
Jun 2, 2026•1:23:27

GitHub's plan for Agents — Kyle Daigle, GitHub

Video
⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build
Jun 3, 2026•38:58

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

🔬Scaling Past Informal AI - Carina Hong, Axiom Math
Jun 3, 2026•1:33:04

🔬Scaling Past Informal AI - Carina Hong, Axiom Math

Video
Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs
Jun 4, 2026•1:15:39

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

Video
🔬 The Self-Driving Lab — Joseph Krause, Radical AI
Jun 17, 2026•1:16:50

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

Video
The Professor of Outputmaxxing — Anjney Midha, AMP
Jun 18, 2026•59:25

The Professor of Outputmaxxing — Anjney Midha, AMP

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan
Jun 22, 2026•1:06:23

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

Video
Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks
Jun 24, 2026•1:08:52

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Video
🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI
Jul 1, 2026•1:48:39

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO
Jul 8, 2026•57:55

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

Video
🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences
Jul 16, 2026•1:41:04

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

Video
🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)
Jul 21, 2026•1:29:47

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

Inside the Model Factory — Eiso Kant, Poolside AI
Jul 23, 2026•1:54:33

Inside the Model Factory — Eiso Kant, Poolside AI

Video
Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI
Jul 28, 2026•1:09:28

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Video
The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten
Aug 3, 2026•1:41:29

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery
Aug 11, 2026•1:35:19

🔬The BioAI Phase Shift - Matthew McPartlon & Neil Patil, Chai Discovery

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