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Latent Space: The AI Engineer Podcast

Latent Space: The AI Engineer Podcast

swyx + Alessio

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The podcast by and for AI Engineers! In 2024, over 2 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space
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The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

The Inference Engineering Masterclass — Philip Kiely & Ali Taha, Baseten

Aug 3, 2026·1:41:29

1:41:29

We first covered Baseten last year when DeepSeek mania was at peak hype. Now they have raised a monster $13B round and become one of the new cohort of AI Infra decacorns that are (with Nvidia, Intel, and the semis...

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Codex from 0 to 10M Users: Building ChatGPT Work — Akshay Nathan, OpenAI

Jul 28, 2026·1:09:28

1:09:28

There are roughly 100x more people who use code than who can write code. As code that “just works” becomes easier to generate, this group may be the biggest prize of all — if you can get the agentic interface right. A...

Inside the Model Factory — Eiso Kant, Poolside AI

Inside the Model Factory — Eiso Kant, Poolside AI

Jul 23, 2026·1:54:33

1:54:33

In recent months, the open vs closed, and US vs China discussions on model ownership and sovereign/local AI have heated up to a fever pitch. So it is very very good news that Poolside AI are finally emerging with new...

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

🔬Causal Models Need Causal Data - Xaira’s X-Cell model for Drug Discovery (Bo Wang & Ci Chu, Chief Discovery Officer & Chief AI Scientist)

Jul 21, 2026·1:29:47

1:29:47

Bet on information If test loss flatlines after 1.5B parameters while training loss continues to drop as you scale, that tells you that your model is limited by the amount of information in your data. Training on a...

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

🔬 The Lab of the Future Should Feel Like a Data Center — Andy Beam & Rafa Gómez-Bombarelli, Lila Sciences

Jul 16, 2026·1:41:04

1:41:04

Imagine a dark warehouse. Racks and racks of devices with wires, tubes, and electronics sticking out. The next AI data center? No. This is Lila Sciences‘ dream for the future of science. A dark warehouse full of...

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

Why AI Infrastructure must evolve for Agent Experience — Akshat Bubna, Modal CTO

Jul 8, 2026·57:55

57:55

We’ve been running a bit of an Agent Cloud series surveying all the top inference/compute/cloud providers, from Databricks to Daytona to Railway and, even further back, E2B, but we’re excited to conclude this series...

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

🔬 The Coolest Diffusion Research Isn't in LLMs — Evan Feinberg & Sergey Edunov, Genesis Molecular AI

Jul 1, 2026·1:48:39

1:48:39

This episode has a fun personal twist: There’s a counterfactual world where I was employee #1 at Genesis Molecular AI, the company behind today’s episode. A certain introduction happened a few weeks too late and I had...

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Why the Frontier Ecosystem must be Open — Matei Zaharia and Reynold Xin, Databricks

Jun 24, 2026·1:08:52

1:08:52

We’re excited to have Databricks join us at AIEWF, among hundreds of the top companies in the AI Engineer ecosystem. LS subscribers can use their discount to get past the late bird pricing and access over $50k in...

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

Red-Teaming after Mythos — Zico Kolter & Matt Fredrikson, Gray Swan

Jun 22, 2026·1:06:23

1:06:23

AI Engineer World’s Fair regular bird tix will sell out ~today! Join us next week ahead of the Late Bird price hike and get >$40,000 in sponsor credits for attending! Thanks to the US Government issuing an export...

The Professor of Outputmaxxing — Anjney Midha, AMP

The Professor of Outputmaxxing — Anjney Midha, AMP

Jun 18, 2026·59:25

59:25

Last 4 days before regular tickets sell out at AI Engineer World’s Fair - this is the single biggest gathering of AI Engineers, Founders, Leaders, and Researchers in the world. Attendees get >$5000 worth of sponsor...

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

🔬 The Self-Driving Lab — Joseph Krause, Radical AI

Jun 17, 2026·1:16:50

1:16:50

On the Science pod, we’ve been covering a lot of the ground on how AI is revolutionizing STEM, but one of our favorite off the record topics since our launch is which field is harder to accelerate: math, bio, or...

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

Reality: The Final Eval — Lukas Petersson and Axel Backlund of Andon Labs

Jun 4, 2026·1:15:39

1:15:39

The new AIEWF website is live! Get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in credits and free AIE WF tickets! Most industry benchmarks compress intelligence and...

🔬Scaling Past Informal AI - Carina Hong, Axiom Math

🔬Scaling Past Informal AI - Carina Hong, Axiom Math

Jun 3, 2026·1:33:04

1:33:04

In 2025, seven-month-old startup Axiom solved all 12 of the problems Putnam exam (scoring 8/12 in the time limit) a prestigious undergraduate math exam. The 12/12 score is better than the top undergraduates (110/120)...

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

⚡️Satya Nadella: No Priors x Latent Space Crossover Special at Microsoft Build

Jun 3, 2026·38:58

38:58

We’ve informally heard that Satya is a listener to LS for a couple years now, but it was still absolutely surreal to meet him and do a live pod at Build, together with our friends at No Priors, the leading VC AI Podcast...

GitHub's plan for Agents — Kyle Daigle, GitHub

GitHub's plan for Agents — Kyle Daigle, GitHub

Jun 2, 2026·1:23:27

1:23:27

I’m excited to work with Microsoft once again as the presenting sponsors of the AI Engineer World’s Fair! We’ll streaming live from MS Build today for a special crossover pod with our friends at No Priors and the one...

Why Video Agent models are next — Ethan He, xAI Grok Imagine

Why Video Agent models are next — Ethan He, xAI Grok Imagine

Jun 1, 2026·1:43:26

1:43:26

We’re announcing AIEWF speakers this week! Take the AI Engineering Survey! Today’s guest Ethan first joined us for the LS Paper Club as the lead on NVIDIA Cosmos World Model, but then joined xAI and built Grok Imagine...

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

The Age of Async Agents — Cognition's Walden Yan & OpenInspect's Cole Murray

May 28, 2026·1:08:02

1:08:02

The new AIEWF website is live! CFPs close in 2 days and we will run our first New Engineer Orientation this weekend, get your tickets booked ASAP as they -will- sell out. Take the AI Engineering Survey and get >$2k in...

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

🔬ESM: The Bitter Lesson is Coming for Proteins - Alex Rives, BioHub

May 27, 2026·1:10:12

1:10:12

Editor’s note: In our first BioHub pod with Priscilla and Mark they discussed their acquisition of EvoScale, led by Alex Rives, who is now Head of Science at BioHub. With ESM-1 they trained language models on millions...

Giving Agents Computers — Ivan Burazin, Daytona

Giving Agents Computers — Ivan Burazin, Daytona

May 21, 2026·1:10:27

1:10:27

Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets! On the product side, everyone is getting Computer - Perplexity, Manus, Cursor, and so on. Meanwhile on the research side, agentic evals...

Railway: The Agent-Native Cloud — Jake Cooper

Railway: The Agent-Native Cloud — Jake Cooper

May 20, 2026·1:28:34

1:28:34

Take the 2026 AI Engineering Survey and get >$2k in credits and AIE WF tickets! This was recorded before Railway suffered a major GCP outage on May 19, despite being a multi-AZ, multi-zone mesh ring, with HA fiber...

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

The Autonomous Drone Tech Stack & Economics of Drones — Yaroslav Azhnyuk, The Fourth Law & Guest Host Noah Smith, Noahpinion

May 18, 2026·1:59:28

1:59:28

The future of war has been evolving before our eyes in Ukraine, yet the west still plans to fight the last war. In this special episode, guest host Noah Smith (@noahpinion) and Brandon Anderson sit down with Yaroslav...

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

AI-Native Healthcare: 100M Doctor Visits, 10–20 Hours Saved, Prior Auth in Minutes — Janie Lee & Chai Asawa, Abridge

May 14, 2026·1:05:20

1:05:20

Special discounts up for AIE Melbourne (LS discount) and AIE World’s Fair (group discounts up to 25% - CFPs still open for Autoresearch and Vertical AI) Cya there! Abridge did not start as an “GPT wrapper”. It was...

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

🔬Doing Vibe Physics — Alex Lupsasca, OpenAI

May 5, 2026·1:31:51

1:31:51

Some people are going crazy over GPT 5.5. Some people. This is the story of the Jagged Frontier. People who use AI to write emails or even code implementation work find the lift moderate whereas people pushing the...

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

Physical AI that Moves the World — Qasar Younis & Peter Ludwig, Applied Intuition

Apr 27, 2026·1:12:21

1:12:21

From building Applied Intuition from YC-era autonomy tooling into a $15B physical AI company, Qasar Younis and Peter Ludwig have spent the last decade living through the full arc of autonomy: from simulation and data...

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

AIE Europe Debrief + Agent Labs Thesis: Unsupervised Learning x Latent Space Crossover Special (2026)

Apr 23, 2026·54:52

54:52

Today, we check in a year after the first Unsupervised Learning x Latent Space Crossover special to discuss everything that has changed (there is a lot) in the world of AI. This episode was recorded just after AIE...

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