What if aging isn’t simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive.
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00:00 — Why Aging Is A Defect In Repair, Not Wear And Tear
01:42 — Meet Dr. Andrew Salzman: Harvard ICU Doctor & NAD Pioneer
03:07 — The 1991 Discovery That Changed Leaky Gut Research
06:59 — Why Doctors Dismissed Leaky Gut For Years
09:46 — DNA Damage, PARP Activation & The NAD Collapse
12:41 — How PARP Inhibitors Stopped Leaky Gut In The Lab
14:35 — What NAD Actually Does Inside Your Cells
21:31 — Best Food Sources For NAD & Creatine Support
24:55 — How Chronic Inflammation Activates PARP
25:56 — CD38: The Enzyme Draining Your NAD With Age
27:10 — NR vs NMN vs Niacin: Which NAD Supplement Makes Sense?
30:02 — Why NAD Is The “Centerpiece Of Biology”
34:24 — The Mouse Study Linking CD38, NAD & Ovarian Aging
35:30 — Why The Brain Is So Vulnerable To Low Cellular Energy
36:57 — Mitochondria As Power Stations: Why ATP Still Needs Delivery
39:31 — Butyrate, Brown Rice & Foods That Help Seal The Gut
41:59 — Flagella, LPS & The Hidden Drivers Of Gut Inflammation
43:36 — Dr. Salzman’s Top Longevity Priorities
45:45 — The New Definition Of Aging: Failed Repair
48:55 — Why Older Bodies Can Be “Operating On Fumes”
51:16 — NAD, Oxygen & Tissue Repair After Major Injury
55:35 — Creatine Dosage, Daily Loss & Why Supplementing May Matter
57:54 — Where To Find Dr. Salzman’s Research
59:01 — Final Thoughts: NAD, Creatine & Cellular Longevity
DISCLAIMER
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
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