After the assassination of her husband Girolamo Riario , Caterina is in full control as regent for her son, Ottaviano Riario. She has to navigate regional issues in Romagna , another assassination in Faenza and then the tricky balancing act during the descent of Charles VIII of France. During all of this she managed to start a new passionate relationship with Giacomo Feo, which will also end in murder and in her thirst for vengeance, Caterina will lose sight of her role as a head of state.